Characterisation of antibodies to insulin to help diagnose factitious hypoglycaemia.

Diagnosis and management of hypoglycaemia due to pancreatic insulin-secreting neoplasia in a German shepherd dog

A 7-year-old castrated male German shepherd dog was presented with a 10-day history of intermittent lethargy, weakness and episodic seizures. Laboratory findings after admission revealed hypoglycaemia and hyperinsulinaemia. Provisional diagnosis of insulinoma was made based on the presence of concurrent hypoglycaemia and elevated insulin level. In exploratory laparotomy a small nodular mass was...

Prevalence of factitious hypoglycaemia associated with sulphonylurea drugs in France in the year 2000.

Hypoglycaemia presents important diagnostic and therapeutic problems. Severe and repetitive hypoglycaemic episodes without treatment may be difficult to explain. Failure to identify factitious hypoglycaemia may lead to laparotomy or pancreatectomy [1, 2]. To estimate the prevalence of factitious hypoglycaemia due to sulphonylurea drugs in patients with unexplained severe hypoglycaemia, we condu...

Accidental gonococcal infection of the eyes in children.

The differential diagnosis, which lay between insulinoma, extrapancreatic tumour, hepatic disease, and endocrine disease, was narrowed after investigation to an insulinoma or an extrapancreatic tumour. Normally blood insulin values would have established the diagnosis, but they would have been misleading in this case and could have led to a pancreatectomy. Cases such as this fulfil all the crit...

C-peptide suppression test and sulphonylurea-induced factitious hypoglycaemia.

Molecular mechanisms of neonatal hyperinsulinism.

Congenital hyperinsulinism (CHI), characterized by profound hypoglycaemia related to inappropriate insulin secretion, may be associated histologically with either diffuse insulin hypersecretion or focal adenomatous hyperplasia, which share a similar clinical presentation, but result from different molecular mechanisms. Whereas diffuse CHI is of autosomal recessive, or less frequently of autosom...